Viagra Originally developed to fight Angina Pain, but later taken as Erectile Dysfunction Drug, has got a new role. The Famous Male Sexual Power Drug can also be effective in Cardiac Hypertrophy. Hypertrophy, or thickening, of the heart muscle occurs in response to increased stress on the heart. It typically involves the ventricles (lower portions of human heart). The most common causes of hypertrophy are related to increased blood pressure in either the lungs or the body.

Viagra scientifically known as sildenafil citrate was good in treatment of enlargement and thickening of the heart in male mice. Viagra was also effective in controlling the further growth of the heart muscle. Sildenafil has shown positive results as it reversed the growth and damage that had already taken place in the heart.

Viagra works, both in the heart and the penis, by inhibiting an enzyme called PDE5A.

In the penis, however, PDE5A relaxes the smooth muscle, allowing the blood to flow and nature to resume its course.

By contrast, in the heart muscle, rather than producing a direct relaxation response, PDE5A helps break down cyclic GMP, a molecule that acts to curb stresses and overgrowth in the heart.

Experts had not previously known that PDE5A was involved in heart function. They had also suspected that excessive heart muscle growth was an adaptive response to malfunction in the heart.

High blood pressure, or hypertension, is the most frequent cause of left ventricular hypertrophy.

Effects of Heart Enlargement

ll forms of cardiac enlargement are abnormal and associated with further problems, including heart failure, irregular heart rhythms , and an increased risk of angina  and heart attack. Heart failure results because thickened or dilated heart muscle cannot function effectively as a pump. The diseased muscle cells in both types of enlargement are also capable of causing irregular heart rhythms that can lead to passing-out or sudden death.

Those with valvular heart disease should have their condition treated with medication. Depending on a variety of factors, heart valve replacement or repair – either through “open heart” surgery or with a catheter entering the heart through a blood vessel at the groin, in a procedure similar to that used for a coronary angiogram.

Viagra was originally developed to dilate coronary blood vessels in people with angina. It didn't work well for angina pain but was revealed to have the erectile dysfunction effect and became a medicine for re-gaining sexual powers.

(Mehar Grewal, Skin Care India)